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. 1999 Aug 27;285(5432):1393-6.
doi: 10.1126/science.285.5432.1393.

Dual function of the selenoprotein PHGPx during sperm maturation

F Ursini  1 , S Heim, M Kiess, M Maiorino, A Roveri, J Wissing, L Flohé
Affiliations

Dual function of the selenoprotein PHGPx during sperm maturation

F Ursini et al. Science. .

Abstract

The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its physical characteristics and biological functions during sperm maturation. PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross-linked, insoluble protein. In the midpiece of mature spermatozoa, PHGPx protein represents at least 50 percent of the capsule material that embeds the helix of mitochondria. The role of PHGPx as a structural protein may explain the mechanical instability of the mitochondrial midpiece that is observed in selenium deficiency.

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