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Review
. 1999 Aug 31;96(18):9989-90.
doi: 10.1073/pnas.96.18.9989.

Amyloid diseases: abnormal protein aggregation in neurodegeneration

E H Koo  1 , P T Lansbury Jr, J W Kelly
Affiliations
Review

Amyloid diseases: abnormal protein aggregation in neurodegeneration

E H Koo et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Atomic-force microscopy of Aβ1–40 demonstrating assembly of amyloid fibrils from protofibrils. Preincubated Aβ1–40 (100 μM) was seeded with preformed fibrils amounting to ≈1% of the initial Aβ1–40 concentration. The aggregates were analyzed 7 days later. In this image, protofibrils appear as smaller and more flexible aggregates (≈4 nm in height) whereas the amyloid fibrils are substantially longer and more rigid (≈8 nm). (Bar = 200 nm.) [Reproduced with permission from ref. (Copyright 1997).]
See this image and copyright information in PMC

References

    1. Trojanowski J Q, Goedert M, Iwatsubo T, Lee V M Y. Cell Death Diff. 1998;5:832–837. - PubMed
    1. Harper J D, Lansbury P T., Jr Annu Rev Biochem. 1997;66:385–407. - PubMed
    1. Jarrett J T, Lansbury P T., Jr Biochemistry. 1992;15:12345–12352. - PubMed
    1. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird T D, Hardy J, Hutton M, Kukull W, et al. Nat Med. 1996;2:864–870. - PubMed
    1. Raby C A, Morganti-Kossmann M C, Kossmann T, Stahel P F, Watson M D, Evans L M, Mehta P D, Spiegel K, Kuo Y M, Roher A E, Emmerling M R, et al. J Neurochem. 1998;71:2505–2509. - PubMed