Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1999 Sep;10(1):1-9.
doi: 10.1016/s0966-6362(99)00012-0.

Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy

D H Sutherland  1 , K R Kaufman, M P Wyatt, H G Chambers, S J Mubarak
Affiliations
Clinical Trial

Double-blind study of botulinum A toxin injections into the gastrocnemius muscle in patients with cerebral palsy

D H Sutherland et al. Gait Posture. 1999 Sep.

Abstract

The purpose of this study was to quantify the gait of subjects receiving two injections of either botulinum A toxin or saline vehicle into the gastrocnemius muscle(s). The study group consisted of cerebral palsy patients who walked with an equinus gait pattern. This study was a randomized, double-blinded, parallel clinical trial of 20 subjects. All were studied by gait analysis before and after the injections. There were no adverse effects. Peak ankle dorsiflexion in stance and swing significantly improved in subjects who received the drug and not in controls. Results of this double blind study give support to the short term efficacy of botulinum toxin A to improve gait in selected patients with cerebral palsy.

PubMed Disclaimer

Publication types

MeSH terms