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. 1999 Jun-Jul;18(6-7):1339-41.
doi: 10.1080/07328319908044710.

Synthesis and biological evaluation of modified DNA fragments for the study of nucleotide excision repair in E. coli

V Monaco  1 , K I van de Wetering, N J Meeuwenoord, H A van den Elst, H R Stuivenberg, R Visse, J C van der Kaaden, G F Moolenaar, E E Verhoeven, N Goosen, G A van der Marel, J H van Boom
Affiliations

Synthesis and biological evaluation of modified DNA fragments for the study of nucleotide excision repair in E. coli

V Monaco et al. Nucleosides Nucleotides. 1999 Jun-Jul.

Abstract

Three new cholesterol-containing phosphoramidites where synthesized and used in automated synthesis of modified DNA fragments. These cholesterol lesions are good substrates for the E. coli UvrABC endonuclease. In vitro they are incised from damaged DNA with higher efficiency in respect with the cholesterol lesions previously published.

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