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. 1999 Aug 16;9(16):2447-52.
doi: 10.1016/s0960-894x(99)00404-7.

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

R M Schelkun  1 , P Yuen, T C Malone, D M Rock, S Stoehr, B Szoke, K Tarczy-Hornoch
Affiliations

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

R M Schelkun et al. Bioorg Med Chem Lett. .

Abstract

Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein.

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