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Review
. 1999 Sep 6;190(5):591-5.
doi: 10.1084/jem.190.5.591.

Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes

J M Wang  1 , J J Oppenheim
Affiliations
Review

Interference with the signaling capacity of CC chemokine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes

J M Wang et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Putative effect of PTX on cell activation. PTX binds to a yet to be defined cell surface receptor through the subunit B-oligomer, which enables the entry of the A-protomer. The A-protomer inhibits Gi protein activation of CCR5 in response to chemokines, whereas the B-oligomer elicits a series of cellular signaling events that may lead to desensitization of CCR5. DAG, diacylglycerol; GD(T)P, guanosine di(tri)phosphate; GRK, G protein–coupled receptor kinase; IP, inositol phosphate; MAPK, mitogen-activated protein kinase; PI3K, phosphatidylinositol 3-kinase; PIP3, phosphatidylinositol trisphosphate; PLC(D), phospholipase C(D).
See this image and copyright information in PMC

Comment on

References

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