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. 1999 Jul;43(2):175-82.
doi: 10.1016/s0165-0378(99)00032-7.

Role of HLA-G versus HLA-E on NK function: HLA-G is able to inhibit NK cytolysis by itself

I Khalil-Daher  1 , B Riteau, C Menier, C Sedlik, P Paul, J Dausset, E D Carosella, N Rouas-Freiss
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Role of HLA-G versus HLA-E on NK function: HLA-G is able to inhibit NK cytolysis by itself

I Khalil-Daher et al. J Reprod Immunol. 1999 Jul.

Abstract

Recent studies have shown that endogenous HLA-E molecules are stabilized on the cell surface upon the expression of HLA-G which contains within its leader sequence, a nonapeptide capable of binding with the HLA-E/beta2m complex. Since HLA-E was found to be the major ligand for the CD94/NKG2A inhibitory receptor, we determined the role of HLA-G versus HLA-E on NK lysis inhibition. We showed that K562 cells transfected with HLA-G1 cDNA are protected from NK lysis by direct interaction between HLA-G1 and killing inhibitory receptor(s). This NK lysis inhibition is not dependent on HLA-E expression, since no HLA-E protein was detected on K562 cells; HLA-G1 is therefore able to inhibit NK lysis by itself.

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