Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Oct;65(4):1170-7.
doi: 10.1086/302577.

A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission

D Clayton  1
Affiliations

A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission

D Clayton. Am J Hum Genet. 1999 Oct.

Abstract

A new transmission/disequilibrium-test statistic is proposed for situations in which transmission is uncertain. Such situations arise when transmission of a multilocus marker haplotype is considered, since haplotype phase is often unknown in a substantial number of instances. Even for single-locus markers, transmission is uncertain if one or both parents are missing. In both these situations, uncertainty may be reduced by the typing of further siblings, whose disease status may be unaffected or unknown. The proposed test is a score test based on a partial score function that omits the terms most influenced by hidden population stratification.

PubMed Disclaimer

Comment in

References

Electronic-Database Information

    1. Medical Research Council Biostatistics Unit, http://www.mrc-bsu.cam.ac.uk (for TRANSMIT program)

References

    1. Bickeböller H, Clerget-Darpoux F (1995) Statistical properties of the allelic and genotypic transmission disequilibrium test for multiallelic markers. Genet Epidemiol 12:865–870 - PubMed
    1. Boehnke M, Langefeld CD (1998) Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am J Hum Genet 62:950–961 - PMC - PubMed
    1. Clayton D, Jones H (1999) Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet 65:1161–1169 (in this issue) - PMC - PubMed
    1. Curtis D (1997) Use of siblings as controls in case-control association studies. Ann Hum Genet 61:319–333 - PubMed
    1. Curtis D, Sham PC (1995) A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet 56:811–812 - PMC - PubMed

Substances

LinkOut - more resources