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. 1978 Dec;19(6):535-9.
doi: 10.1111/j.1528-1157.1978.tb05033.x.

Ethosuximide pharmacokinetics in a pregnant patient and her newborn

J R Koup, J Q Rose, M E Cohen

Ethosuximide pharmacokinetics in a pregnant patient and her newborn

J R Koup et al. Epilepsia. 1978 Dec.

Abstract

Ethosuximide concentration in serum was monitored during the last trimester of pregnancy in a patient. After delivery, the decline in serum concentration of ethosuximide was observed in the nonnursing neonate. The half-life of elimination of transplacentally acquired ethosuximide in this neonate was 41.3 hr. The ratio of breast milk to maternal serum concentration of ethosuximide was approximately 1. A total daily exposure to ethosuximide of 12.8 to 38.4 mg (3.6 to 11.0 mg/kg) as a result of nursing was predicted.

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