Review
doi: 10.1042/bse0330165.
The matter of mind: molecular control of memory
Affiliations
- PMID: 10488449
- DOI: 10.1042/bse0330165
Item in Clipboard
Review
The matter of mind: molecular control of memory
Essays Biochem.
1998.
Abstract
A widely accepted hypothesis suggests that changes in synaptic strength underlie the formation of memories in the brain. LTP is a mechanism of synaptic strengthening. Induction of LTP depends on NMDA receptor activation, and its expression depends in part on protein kinase activity. Studies of knock-out mice suggest that LTP is critical for hippocampus-based memory. Genetic studies in Drosophila implicate cAMP metabolism in classical conditioning, a form of unconscious memory. Consolidating memories for long-term retention depends on the cAMP-inducible transcription factor CREB.
Similar articles
-
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.Int J Dev Neurosci. 2001 Jul;19(4):387-94. doi: 10.1016/s0736-5748(00)00094-0. Int J Dev Neurosci. 2001. PMID: 11378299
-
Plasticity, hippocampal place cells, and cognitive maps.Arch Neurol. 2001 Jun;58(6):874-81. doi: 10.1001/archneur.58.6.874. Arch Neurol. 2001. PMID: 11405801 Review.
-
Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors.J Neurosci. 2018 Mar 14;38(11):2863-2876. doi: 10.1523/JNEUROSCI.2362-17.2018. Epub 2018 Feb 13. J Neurosci. 2018. PMID: 29440558 Free PMC article.
-
Memory and the brain: unexpected chemistries and a new pharmacology.Neurobiol Learn Mem. 1998 Jul-Sep;70(1-2):82-100. doi: 10.1006/nlme.1998.3840. Neurobiol Learn Mem. 1998. PMID: 9753589 Review.
-
Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?J Neurosci. 2003 Jul 16;23(15):6304-14. doi: 10.1523/JNEUROSCI.23-15-06304.2003. J Neurosci. 2003. PMID: 12867515 Free PMC article.
Cited by
-
Evolution of motif variants and positional bias of the cyclic-AMP response element.BMC Evol Biol. 2007 Feb 8;7 Suppl 1(Suppl 1):S15. doi: 10.1186/1471-2148-7-S1-S15. BMC Evol Biol. 2007. PMID: 17288573 Free PMC article.
-
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys.Neurotoxicol Teratol. 2011 Mar-Apr;33(2):220-30. doi: 10.1016/j.ntt.2011.01.001. Epub 2011 Jan 15. Neurotoxicol Teratol. 2011. PMID: 21241795 Free PMC article.
-
Differential muscarinic and NMDA contributions to visuo-spatial paired-associate learning in rhesus monkeys.Psychopharmacology (Berl). 2002 Mar;160(3):253-62. doi: 10.1007/s00213-001-0954-5. Epub 2002 Jan 22. Psychopharmacology (Berl). 2002. PMID: 11889494 Free PMC article.
-
Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies.Neurotoxicology. 2012 Aug;33(4):810-6. doi: 10.1016/j.neuro.2011.12.016. Epub 2012 Jan 10. Neurotoxicology. 2012. PMID: 22245043 Free PMC article.
-
Limb Remote Ischemic Preconditioning Reduces Repeated Ketamine Exposure-Induced Adverse Effects in the Developing Brain of Rats.J Mol Neurosci. 2019 May;68(1):58-65. doi: 10.1007/s12031-019-01282-3. Epub 2019 Mar 7. J Mol Neurosci. 2019. PMID: 30847723
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
