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. 1999 Aug;54(2):191-3.
doi: 10.1034/j.1399-0039.1999.540211.x.

Genetic polymorphisms at the tumour necrosis factor loci (TNFA and TNFB) in cardiac sarcoidosis

N Takashige  1 , T K Naruse, A Matsumori, M Hara, S Nagai, S Morimoto, S Hiramitsu, S Sasayama, H Inoko
Affiliations

Genetic polymorphisms at the tumour necrosis factor loci (TNFA and TNFB) in cardiac sarcoidosis

N Takashige et al. Tissue Antigens. 1999 Aug.

Abstract

Many studies have previously confirmed high TNFalpha (tumor necrosis factor-alpha) production in sarcoidosis, and have shown that TNFalpha plays an important role in granuloma formation. We investigated TNFA and TNFB (lymphotoxin-alpha) gene polymorphisms in 26 cardiac sarcoidosis patients of Japanese origin. These studies revealed a significant increase in the more uncommon TNFA2 allele in the patient group, suggesting that the TNFA gene controls the genetic susceptibility to cardiac sarcoidosis.

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