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. 1999 Aug;22(4):367-71.
doi: 10.1007/BF02979059.

Release of renal dipeptidase from rabbit renal proximal tubules and its inhibition by gentamicin

B Y Kang  1 , J S We, K Choi, H B Lee, H J Han, H S Park
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Release of renal dipeptidase from rabbit renal proximal tubules and its inhibition by gentamicin

B Y Kang et al. Arch Pharm Res. 1999 Aug.

Abstract

Effects of several drugs on rabbit renal proximal tubules were examined for the applicability of renal dipeptidase (RDPase, EC 3. 4. 13. 11) release as a model system to study nephrotoxicity. The proximal tubule prepared by the method of Taub (1990) released RDPase spontaneously in the control experiment which was confirmed by Western blotting. RDPase was also released from cisplatin, lipopolysaccharide (LPS), and indomethacin-treated tubules. Gentamicin inhibited RDPase release in a concentration-dependent manner. This RDPase release system may not be a general model to screen nephrotoxicity but could be a useful source of RDPase purification in a simple and inexpensive way.

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