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. 1999 Oct;81(4):339-40.
doi: 10.1136/adc.81.4.339.

Are glomerular filtration rate estimations necessary before high dose methotrexate?

H Rees  1 , I M Hann, J M Chessells, D K Webb
Affiliations

Are glomerular filtration rate estimations necessary before high dose methotrexate?

H Rees et al. Arch Dis Child. 1999 Oct.

Abstract

Glomerular filtration rates (GFR) were estimated in 168 children (227 estimates) before treatment for haematological malignancies with high dose, intravenous methotrexate. Clinical management was altered on the basis of GFR in only two cases, both of whom had tumour lysis syndrome. Routine estimations of GFR do not contribute to management.

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Comment in

  • GFR estimation in paediatric oncology.
    Phillips R, Nicolin G. Phillips R, et al. Arch Dis Child. 2000 May;82(5):428. doi: 10.1136/adc.82.5.428c. Arch Dis Child. 2000. PMID: 10836942 Free PMC article. No abstract available.

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