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. 1979 Jan;137(1):256-63.
doi: 10.1128/jb.137.1.256-263.1979.

Specificity and biological distribution of coenzyme M (2-mercaptoethanesulfonic acid)

W E Balch, R S Wolfe

Specificity and biological distribution of coenzyme M (2-mercaptoethanesulfonic acid)

W E Balch et al. J Bacteriol. 1979 Jan.

Abstract

The specificity of the growth requirement of Methanobacterium ruminantium strain M1 for a new coenzyme, 2-mercaptoethanesulfonic acid (HS--CoM), was examined. A variety of derivatives, analogs, and potential biosynthetic precursors of coenzyme M were tested; only a restricted range of thioether, thioester, and thiocarbonate derivatives of the cofactor were found to replace the HS--CoM requirement. Bromoethanesulfonic acid (BrCH2CH2SO3-), a halogenated analog of HS--CoM, potently inhibited the growth response. No coenzyme was detectable in a wide range of nonmethanogenic eucaryotic tissues and procaryotic organisms. However, all methanogens available in pure culture exhibited high levels of coenzyme M which ranged from 0.3 to 16 nmol/mg of dry weight.

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References

    1. J Bacteriol. 1979 Jan;137(1):264-73 - PubMed
    1. Biochemistry. 1978 Jun 13;17(12):2374-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5088-90 - PubMed
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