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. 1999 Oct;67(10):5518-21.
doi: 10.1128/IAI.67.10.5518-5521.1999.

Role of gamma interferon in controlling murine chlamydial genital tract infection

J I Ito  1 , J M Lyons
Affiliations

Role of gamma interferon in controlling murine chlamydial genital tract infection

J I Ito et al. Infect Immun. 1999 Oct.

Abstract

Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.

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Figures

FIG. 1
FIG. 1
MoPn strain shedding from the genital tract of IFN-γ−/− (■) and normal (129 Sv/Ev) (▵) mice. Each point represents the mean of the log10 IFU  ± standard deviation.
FIG. 2
FIG. 2
Serovar D shedding from the genital tract of IFN-γ−/− (■) and normal (129 Sv/Ev) (▵) mice. Each point represents the mean of the log10 IFU ± standard deviation.
See this image and copyright information in PMC

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