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Comment
. 1999 Sep 28;96(20):10953-4.
doi: 10.1073/pnas.96.20.10953.

NO news is good news

C J Lowenstein
Comment

NO news is good news

C J Lowenstein. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Molecular pathways of ischemic preconditioning. Ischemia triggers an early phase of protection against further episodes of ischemia. The early phase, depicted on the left, begins when ischemia induces the release of adenosine, which binds to the adenosine receptor type I. An intracellular signal transduction pathway is activated by hydrolysis of PIP2, which activates protein kinase C and other protein kinases. Mitochondrial ATP-sensitive potassium channels are then activated, which protect the myocardium by unknown mechanisms. The late phase of protection, depicted on the right, begins when ischemia activates unknown transcription factors, possibly NF-κB and hypoxia-inducible factor 1 (HIF-1), which induce iNOS expression, leading to NO production and then protection of the heart 24–72 h after ischemia.
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