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. 1999 Oct;24(10):385-9.
doi: 10.1016/s0968-0004(99)01451-6.

RMPs: recombination/replication mediator proteins

H T Beernink  1 , S W Morrical
Affiliations

RMPs: recombination/replication mediator proteins

H T Beernink et al. Trends Biochem Sci. 1999 Oct.

Abstract

Enzymes for DNA replication and recombination need to gain access to single-stranded DNA (ssDNA) but ssDNA-binding proteins (SSBs) present an obstacle to the formation of enzyme-ssDNA replication and recombination complexes. A specialized class of SSBs, which we designate as recombination/replication mediator proteins (RMPs), promotes enzyme- ssDNA assembly by overcoming SSB inhibition. RMPs exhibit strong conservation of function across divergent species, and display species-specific interactions with SSB and enzymes to neutralize the SSB barrier to enzyme-ssDNA assembly.

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