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Review
. 1999:457:217-36.

Apoptosis. Molecules and mechanisms

M Konopleva  1 , S Zhao, Z Xie, H Segall, A Younes, D F Claxton, Z Estrov, S M Kornblau, M Andreeff
Affiliations
  • PMID: 10500797
Review

Apoptosis. Molecules and mechanisms

M Konopleva et al. Adv Exp Med Biol. 1999.

Abstract

This review of the molecules and pathways involved in programmed cell death (apoptosis) discriminates triggers of apoptosis (e.g. chemotherapy, radiation, Fas ligation), modulators of apoptosis (e.g. Bcl-2 family members, Bcl-2 interacting proteins, Apafs, IAPs, and Fas/FasL modulators including FLICE and FLIPs), effectors (caspases 1-13) and cleavage substrates (e.g. PARP). Special consideration is given to the structure-function relationship of Bcl-2 family members and to their post-transcriptional modification. Brief references are made to the role of apoptotic pathway in leukemias and lymphomas and to strategies of modulating apoptotic pathways.

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