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Review
. 1999 Oct;56(4):1277-81.
doi: 10.1046/j.1523-1755.1999.00703.x.

Mechanisms of chronic hypoxia-induced renal cell growth

A Sahai  1 , C Mei, R W Schrier, R L Tannen
Affiliations
Free article
Review

Mechanisms of chronic hypoxia-induced renal cell growth

A Sahai et al. Kidney Int. 1999 Oct.
Free article

Abstract

Chronic local tissue hypoxia appears to play an important role in the initiation and progression of chronic renal disease. We examined the effect of local hypoxia on cultured renal tubular epithelial and mesangial cell proliferation, dedifferentiation, and extracellular matrix synthesis. The underlying signaling mechanisms whereby hypoxia induces renal cell growth were evaluated. The roles of protein kinase C, p38 mitogen-activated protein kinase, TGF-beta1, osteopontin, and nitric oxide were determined.

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