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Comment
. 1999 Oct;6(10):900-2.
doi: 10.1038/13260.

Enzymes that push DNA around

J L Keck, J M Berger
Comment

Enzymes that push DNA around

J L Keck et al. Nat Struct Biol. 1999 Oct.

Abstract

DNA topoisomerases are proteins that regulate DNA topology in cells through selective cycles of DNA cleavage, manipulation, and religation. Two papers describe an ensemble of different protein conformations and nucleotide-protein complexes of Escherichia coli topoisomerase. These results lead to new insights about how this enzyme recognizes DNA and catalyzes supercoil relaxation.

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