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Case Reports
. 1999 Oct;83(1):101-3.
doi: 10.1016/s0304-3959(99)00096-2.

Low-dose subcutaneous ketamine infusion and morphine tolerance

R F Bell  1
Affiliations
Case Reports

Low-dose subcutaneous ketamine infusion and morphine tolerance

R F Bell. Pain. 1999 Oct.

Abstract

The NMDA receptor has been reported to be involved in opioid tolerance. Adjuvant subcutaneous infusion treatment with (very) low-dose ketamine, a NMDA receptor antagonist, improves analgesia and at the same time appears to reduce morphine tolerance. Three cases are presented.

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