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. 1979 Jan 1;149(1):279-83.
doi: 10.1084/jem.149.1.279.

Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes

T Yoneda, G R Mundy

Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes

T Yoneda et al. J Exp Med. .

Abstract

The production of osteoclast-activating factor (OAF) by normal human peripheral blood leukocytes stimulated by phytohemagglutinin was inhibited by a series of structurally unrelated inhibitors of prostaglandin synthetase. Inhibition of OAF production by these agents was reversed by adding prostaglandins of the E series back to the leukocyte suspension. These results indicate that prostaglandin synthesis is necessary for OAF production.

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References

    1. J Lab Clin Med. 1975 Jun;85(6):1001-7 - PubMed
    1. J Clin Invest. 1965 Jan;44:103-16 - PubMed
    1. Clin Exp Immunol. 1976 Apr;24(1):42-8 - PubMed
    1. N Engl J Med. 1977 Nov 3;297(18):963-8 - PubMed
    1. J Exp Med. 1977 Dec 1;146(6):1719-34 - PubMed

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