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Review
. 1999 Oct;43(10):2339-44.
doi: 10.1128/AAC.43.10.2339.

Lack of cell wall peptidoglycan versus penicillin sensitivity: new insights into the chlamydial anomaly

J M Ghuysen  1 , C Goffin
Affiliations
Review

Lack of cell wall peptidoglycan versus penicillin sensitivity: new insights into the chlamydial anomaly

J M Ghuysen et al. Antimicrob Agents Chemother. 1999 Oct.
No abstract available

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Figures

FIG. 1
FIG. 1
Lipid II as the immediate biosynthetic precursor of wall peptidoglycan in E. coli and putative glycanless wall polypeptide in C. trachomatis. G, N-acetylglucosamine; M, N-acetylmuramic acid; Dpm, diaminopimelic acid; thick bar, transmembrane C55 lipid. Reaction 1, transglycosylase-catalyzed synthesis of a glycosidic bond. Reaction 2, N-acetylmuramoyl-l-alanine-catalyzed hydrolysis of a d-lactoyl–l-alanine bond. Reactions 3 and 4, acylserine transferase-catalyzed transpeptidations at the expense of the d-alanyl–d-alanine bond of pentapeptide units. The amino acceptors of the transfer reactions are the amino group at the D center of meso-diaminopimelic acid in reaction 3 and the amidase-released l-alanine amino group in reaction 4. The product of reactions 1 and 3 is the wall peptidoglycan. The product of reactions 2, 3, and 4 is the putative wall polypeptide.
FIG. 2
FIG. 2
Modular design of the multimodular PBPs of classes A and B. Indicated are the positions of the five motifs of the transglycosylase n-PB module of class A PBPs (□) and the three motifs of the cell cycle n-PB module of class B PBPs (○). The intermodule junction sites (▵) are common to the PBPs of classes A and B.
FIG. 3
FIG. 3
Occurrence of motifs characteristic of class B PBPs along amino acid sequences of the 647-amino-acid (ORF D270-encoded) PBP and the 1,080-amino-acid (ORFD682-encoded) PBP of C. trachomatis (Ctr). E. coli (Eco) PBP 3 and PBP 2 are the prototypes of PBPs of subclasses B3 and B2, respectively (17). The intermotif distances are in numbers of amino acid residues.
See this image and copyright information in PMC

References

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