Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1999 Oct;43(10):2463-7.
doi: 10.1128/AAC.43.10.2463.

Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits

A H Groll  1 , V Petraitis, R Petraitiene, A Field-Ridley, M Calendario, J Bacher, S C Piscitelli, T J Walsh
Affiliations
Comparative Study

Safety and efficacy of multilamellar liposomal nystatin against disseminated candidiasis in persistently neutropenic rabbits

A H Groll et al. Antimicrob Agents Chemother. 1999 Oct.

Abstract

The activity of liposomal nystatin (L-Nys) against subacute disseminated candidiasis was investigated in persistently neutropenic rabbits. Antifungal therapy was administered for 10 days starting 24 h after intravenous inoculation of 10(3) blastoconidia of Candida albicans. Responses to treatment were assessed by the quantitative clearance of the organism from blood and tissues. Treatments consisted of L-Nys at dosages of 2 and 4 mg/kg of body weight/day (L-Nys2 and L-Nys4, respectively) amphotericin B deoxycholate at 1 mg/kg/day (D-AmB), and fluconazole at 10 mg/kg/day (Flu). All treatments were given intravenously once daily. Compared to the results for untreated but infected control animals, treatment with L-Nys2, L-Nys4, D-AmB, and Flu resulted in a significant clearance of the residual burden of C. albicans from the kidney, liver, spleen, lung, and brain (P < 0.0001 by analysis of variance). When the proportion of animals infected at at least one of the five tissue sites studied was evaluated, a dose-dependent response to treatment with L-Nys was found (P < 0.05). Compared to D-AmB-treated rabbits, mean serum creatinine and blood urea nitrogen levels at the end of therapy were significantly lower in animals treated with L-Nys2 (P < 0.001) and L-Nys4 (P < 0.001 and P < 0.01, respectively). L-Nys was less nephrotoxic than conventional amphotericin B and had dose-dependent activity comparable to that of amphotericin B for the early treatment of subacute disseminated candidiasis in persistently neutropenic rabbits.

PubMed Disclaimer

References

    1. Anaissie E J, Rex J H, Uzun O, Vartivarian S. Predictors of adverse outcome in cancer patients with candidemia. Am J Med. 1998;104:238–245. - PubMed
    1. Berenguer J, Buck M, Witebsky F, Stock F, Pizzo P A, Walsh T J. Lysis-centrifugation blood cultures in the detection of tissue-proven invasive candidiasis. Diagn Microbiol Infect Dis. 1993;17:103–109. - PubMed
    1. Besnard M, Hartmann O, Valteau-Couanet D, Robert M, Brugieres L, Lemerle J. Systemic Candida infection in pediatric BM-autotransplantation: clinical signs, outcome and prognosis. Bone Marrow Transplant. 1993;11:465–470. - PubMed
    1. Boutati E, Maltezou H C, Lopez-Berestein G, Vartivarian S E, Anaissie E. Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, D.C: American Society for Microbiology; 1995. Phase I study of maximum tolerated dose of intravenous liposomal nystatin for the treatment of refractory febrile neutropenia in patients with haematological malignancies, abstr. LM22; p. 330.
    1. Committee on the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council. Guide for the care and use of laboratory animals. Washington, D.C: National Academy Press; 1996.

Publication types