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. 1999 Oct;43(10):2565-8.
doi: 10.1128/AAC.43.10.2565.

Treatment of experimental staphylococcal endocarditis due to a strain with reduced susceptibility in vitro to vancomycin: efficacy of ampicillin-sulbactam

M Backo  1 , E Gaenger, A Burkart, Y L Chai, A S Bayer
Affiliations

Treatment of experimental staphylococcal endocarditis due to a strain with reduced susceptibility in vitro to vancomycin: efficacy of ampicillin-sulbactam

M Backo et al. Antimicrob Agents Chemother. 1999 Oct.

Abstract

We evaluated several 3-day antimicrobial regimens in the treatment of experimental endocarditis caused by an oxacillin-resistant Staphylococcus aureus strain exhibiting intermediate susceptibility in vitro to vancomycin (VISA). Neither vancomycin alone nor trovafloxacin exhibited in vivo efficacy; addition of amikacin to vancomycin yielded a modest in vivo effect. In contrast, the combination of ampicillin and sulbactam was highly effective in vivo, causing a mean decrease in VISA vegetation densities of >5 log(10) CFU/g versus those of untreated controls.

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Figures

FIG. 1
FIG. 1
Timed-kill curve of VISA MU-50 (inoculum, 106) versus the studied antibiotics, each at five times the MIC. Trova, trovafloxacin; Vanco, vancomycin; Vanco+Amk, vancomycin plus amikacin; A+S, ampicillin plus sulbactam; Control, medium alone. Data points represent the means of results from two independent assays performed on different days.
See this image and copyright information in PMC

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