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. 1999 Oct;23(2):159-65.
doi: 10.1038/13787.

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

D A Persons  1 , R F Paulson, M R Loyd, M T Herley, S M Bodner, A Bernstein, P H Correll, P A Ney
Affiliations

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

D A Persons et al. Nat Genet. 1999 Oct.

Abstract

The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

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Comment in

  • A friendly signal.
    Schwartzberg PL. Schwartzberg PL. Nat Genet. 1999 Oct;23(2):128-30. doi: 10.1038/13753. Nat Genet. 1999. PMID: 10508499 No abstract available.

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