Review
doi: 10.1016/s0958-1669(99)00012-9.
Engineering the mouse genome by site-specific recombination
Affiliations
- PMID: 10508631
- DOI: 10.1016/s0958-1669(99)00012-9
Item in Clipboard
Review
Engineering the mouse genome by site-specific recombination
Curr Opin Biotechnol.
1999 Oct.
Abstract
Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.
Similar articles
-
Engineering chromosomal rearrangements in mice.Nat Rev Genet. 2001 Oct;2(10):780-90. doi: 10.1038/35093564. Nat Rev Genet. 2001. PMID: 11584294 Review.
-
"Cre"-ating mouse mutants-a meeting review on conditional mouse genetics.Genes Dev. 1999 Jan 15;13(2):142-5. doi: 10.1101/gad.13.2.142. Genes Dev. 1999. PMID: 9925637 No abstract available.
-
Engineering adenovirus genome by bacterial artificial chromosome (BAC) technology.Methods Mol Biol. 2014;1089:143-58. doi: 10.1007/978-1-62703-679-5_11. Methods Mol Biol. 2014. PMID: 24132484
-
Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications.Mol Cell Biol. 2000 Jan;20(2):648-55. doi: 10.1128/MCB.20.2.648-655.2000. Mol Cell Biol. 2000. PMID: 10611243 Free PMC article.
-
When reverse genetics meets physiology: the use of site-specific recombinases in mice.FEBS Lett. 2002 Oct 2;529(1):116-21. doi: 10.1016/s0014-5793(02)03266-0. FEBS Lett. 2002. PMID: 12354622 Review.
Cited by
-
Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline.Int J Med Sci. 2004;1(2):76-91. doi: 10.7150/ijms.1.76. Epub 2004 Jun 1. Int J Med Sci. 2004. PMID: 15912200 Free PMC article.
-
When Cre-mediated recombination in mice does not result in protein loss.Genetics. 2010 Nov;186(3):959-67. doi: 10.1534/genetics.110.121608. Epub 2010 Sep 2. Genetics. 2010. PMID: 20813881 Free PMC article.
-
Gene discovery and gene function assignment in filamentous fungi.Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5110-5. doi: 10.1073/pnas.091094198. Epub 2001 Apr 10. Proc Natl Acad Sci U S A. 2001. PMID: 11296265 Free PMC article.
-
Inducible model for beta-six-mediated site-specific recombination in mammalian cells.Nucleic Acids Res. 2006 Jan 3;34(1):e1. doi: 10.1093/nar/gnj001. Nucleic Acids Res. 2006. PMID: 16394020 Free PMC article.
-
The order of strand exchanges in Cre-LoxP recombination and its basis suggested by the crystal structure of a Cre-LoxP Holliday junction complex.J Mol Biol. 2002 May 24;319(1):107-27. doi: 10.1016/S0022-2836(02)00246-2. J Mol Biol. 2002. PMID: 12051940 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
