Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Oct;10(5):470-6.
doi: 10.1016/s0958-1669(99)00012-9.

Engineering the mouse genome by site-specific recombination

D Metzger  1 , R Feil
Affiliations
Review

Engineering the mouse genome by site-specific recombination

D Metzger et al. Curr Opin Biotechnol. 1999 Oct.

Abstract

Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.

PubMed Disclaimer

LinkOut - more resources