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Review
. 1999 Oct;3(5):578-83.
doi: 10.1016/s1367-5931(99)00012-5.

Type II restriction endonucleases: structural, functional and evolutionary relationships

R A Kovall  1 , B W Matthews
Affiliations
Free article
Review

Type II restriction endonucleases: structural, functional and evolutionary relationships

R A Kovall et al. Curr Opin Chem Biol. 1999 Oct.
Free article

Abstract

Type II restriction endonucleases are a paradigm for site-specific cleavage of DNA. Recent structural analyses, in particular in the presence of various divalent metals, have shed new insight into the mechanisms of catalysis. In addition, during this past year the crystal structure determinations of MutH, lambda-exonuclease and FokI have revealed that these proteins are also members of the same family.

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