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Review
. 1999 Oct;9(5):595-603.
doi: 10.1016/s0959-437x(99)00016-7.

APC: the plot thickens

M Bienz  1
Affiliations
Review

APC: the plot thickens

M Bienz. Curr Opin Genet Dev. 1999 Oct.

Abstract

Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.

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