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. 1999 Oct;11(5):527-31.
doi: 10.1016/s0952-7915(99)00011-4.

Recent advances in xenotransplantation

M S Sandrin  1 , I F McKenzie
Affiliations

Recent advances in xenotransplantation

M S Sandrin et al. Curr Opin Immunol. 1999 Oct.

Abstract

The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galalpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galalpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.

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