doi: 10.1016/s0952-7915(99)00011-4.
Recent advances in xenotransplantation
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- PMID: 10508710
- DOI: 10.1016/s0952-7915(99)00011-4
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Recent advances in xenotransplantation
Curr Opin Immunol.
1999 Oct.
Abstract
The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galalpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galalpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.
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