Review
doi: 10.1016/s1369-5274(99)00008-9.
Mechanism of fluoroquinolone action
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- PMID: 10508721
- DOI: 10.1016/s1369-5274(99)00008-9
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Review
Mechanism of fluoroquinolone action
Curr Opin Microbiol.
1999 Oct.
Abstract
When fluoroquinolones bind to gyrase or topoisomerase IV in the presence of DNA, they alter protein conformation. DNA cleavage results with diminished religation, so the enzymes are trapped in ternary complexes with drug and cleaved DNA. Preferential localization of gyrase ahead of replication forks and topoisomerase IV behind them causes fluoroquinolone-mediated complexes with the two enzymes to have different physiological consequences.
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