Bilateral field advantage and evoked potential interhemispheric transmission in commissurotomy and callosal agenesis

Abstract

The role of the corpus callosum versus other cerebral commissures in the interhemispheric integration of visual information was studied in four individuals with complete agenesis of the corpus callosum, two individuals with partial agenesis, one total commissurotomy patient, and normal individuals. Evoked potential (EP) indices of interhemispheric transmission of visual sensory responses were observed during matching of unilateral and bilateral visual field letters and patterns. Neither the commissurotomy nor any of the acallosal patients had ipsilateral hemisphere visual EPs (P1 and N1), demonstrating that the posterior callosum is necessary for interhemispheric transmission of these components of visual evoked potentials. While the commissurotomy patient could not compare bilaterally presented letters, the anterior commissure of the acallosal patients appeared to be sufficient for interhemispheric comparison of single letters. However, bilateral comparison of more complex visual patterns resulted in considerable difficulty for complete agenesis patients, while comparison of patterns was more nearly normal when anterior callosal fibers were present (partial agenesis).