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. 1999 Aug 31;68(3-4):265-72.
doi: 10.1016/s0378-1135(99)00078-4.

Salmonella Abortusequi strains of equine origin harbor a 95kb plasmid responsible for virulence in mice

M Akiba  1 , T Sameshima, T Anzai, R Wada, M Nakazawa
Affiliations

Salmonella Abortusequi strains of equine origin harbor a 95kb plasmid responsible for virulence in mice

M Akiba et al. Vet Microbiol. .

Abstract

Most Salmonella choleraesuis subsp. choleraesuis serovar Abortusequi strains of equine origin harbor a 95kb plasmid, pSA95. Results of PCR and Southern blot analysis suggest that pSA95 contains spv genes. A pSA95-cured strain of S. Abortusequi was 48 times less virulent to mice than its parental strain. Virulence was restored by reintroduction of pSA95. These results provide clear evidence that pSA95 confers virulence on S. Abortusequi in mice. This is the first report describing a virulence plasmid of S. Abortusequi.

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