Can we just say NO to sickle cell anemia?

R L Nagel¹

Affiliations

Comment

R L Nagel. J Clin Invest. 1999 Oct.

. 1999 Oct;104(7):847-8.

doi: 10.1172/JCI8379.

R L Nagel¹

¹ Albert Einstein College of Medicine, Division of Hematology, 1300 Morris Park Avenue, Ullman 921, Bronx, New York 10461, USA.

No abstract available

Comment on

Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.
Head CA, Brugnara C, Martinez-Ruiz R, Kacmarek RM, Bridges KR, Kuter D, Bloch KD, Zapol WM. Head CA, et al. J Clin Invest. 1997 Sep 1;100(5):1193-8. doi: 10.1172/JCI119631. J Clin Invest. 1997. PMID: 9276736 Free PMC article.
Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity.
Gladwin MT, Schechter AN, Shelhamer JH, Pannell LK, Conway DA, Hrinczenko BW, Nichols JS, Pease-Fye ME, Noguchi CT, Rodgers GP, Ognibene FP. Gladwin MT, et al. J Clin Invest. 1999 Oct;104(7):937-45. doi: 10.1172/JCI7637. J Clin Invest. 1999. PMID: 10510334 Free PMC article.

1. Gladwin MT, et al. Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. J Clin Invest. 1999;104:937–945. - PMC - PubMed
1. Head CA, et al. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest. 1997;100:1193–1198. - PMC - PubMed
1. Ignarro LJ. A novel signal transduction mechanism for transcellular communication. Hypertension. 1990;16:477–483. - PubMed
1. Moncada S. Nitric oxide: discovery and impact on clinical medicine. J R Soc Med. 1999;92:164–169. - PMC - PubMed
1. Gow AJ, Stamler JS. Reactions between nitric oxide and haemoglobin under physiological conditions. Nature. 1998;391:169–173. - PubMed