Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Oct 8;286(5438):304-6.
doi: 10.1126/science.286.5438.304.

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

D Salvemini  1 , Z Q Wang, J L Zweier, A Samouilov, H Macarthur, T P Misko, M G Currie, S Cuzzocrea, J A Sikorski, D P Riley
Affiliations

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

D Salvemini et al. Science. .

Abstract

Many human diseases are associated with the overproduction of oxygen free radicals that inflict cell damage. A manganese(II) complex with a bis(cyclohexylpyridine)-substituted macrocyclic ligand (M40403) was designed to be a functional mimic of the superoxide dismutase (SOD) enzymes that normally remove these radicals. M40403 had high catalytic SOD activity and was chemically and biologically stable in vivo. Injection of M40403 into rat models of inflammation and ischemia-reperfusion injury protected the animals against tissue damage. Such mimics may result in better clinical therapies for diseases mediated by superoxide radicals.

PubMed Disclaimer

Comment in

MeSH terms

LinkOut - more resources