Maternal effect of Type 2 diabetes mellitus on insulin sensitivity and metabolic profile in healthy young Mexicans

Abstract

The objective of this study was to identify the maternal effect of Type 2 diabetes mellitus (T2DM) on insulin sensitivity and metabolic profiles of young healthy, Mexican people (n=15). A cross-sectional study was performed in these subjects with a family history of T2DM in both first and second degree relatives on the maternal side and 15 control subjects. The following tests were carried out: insulin tolerance test and metabolic profile. Systolic blood pressure and serum uric acid were significantly higher in probands than controls. Insulin sensitivity was not different between either group studied (4.7+/-0.9 in probands vs 4.5+/-0.8%/min in controls; p=0.52).

In conclusion: family history of T2DM on the maternal side increased both systolic blood pressure and serum uric acid level in probands, without modification in their insulin sensitivity. Triglycerides concentration had a tendency to be higher in probands than controls.