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. 1999 Sep;88(9):933-6.
doi: 10.1080/08035259950168397.

Prevalence of coeliac disease in Turner syndrome

S A Ivarsson  1 , A Carlsson, A Bredberg, J Alm, S Aronsson, J Gustafsson, L Hagenäs, A Häger, B Kriström, C Marcus, C Moëll, K O Nilsson, T Tuvemo, O Westphal, K Albertsson-Wikland, J Aman
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Prevalence of coeliac disease in Turner syndrome

S A Ivarsson et al. Acta Paediatr. 1999 Sep.

Abstract

This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA-antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA-positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.

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