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. 1999 Sep;106(4):1037-40.
doi: 10.1046/j.1365-2141.1999.01636.x.

Acute lymphoblastic leukaemia occurring as second malignancy: report of the GIMEMA archive of adult acute leukaemia. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto

L Pagano  1 , A Pulsoni, M E Tosti, L Annino, A Mele, A Camera, B Martino, C Guglielmi, R Cerri, E Di Bona, R Invernizzi, C Castagnola, R Bassan, L Mele, G Todeschini, G Leone, F Mandelli
Affiliations

Acute lymphoblastic leukaemia occurring as second malignancy: report of the GIMEMA archive of adult acute leukaemia. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto

L Pagano et al. Br J Haematol. 1999 Sep.

Abstract

Between July 1992 and June 1996, 901 new cases of adult acute lymphoblastic leukaemia were recorded in the GIMEMA Archive of Adult Acute Leukaemia; 21 of them (2.3%) had a previous primary malignancy (PM). We found that secondary acute lymphoblastic leukaemia cases (sALL) presented with older age, a high incidence of pre-pre-B immunophenotype and a significantly higher prevalence of cancer among relatives compared to de novo ALL. The leukaemogenic activity of the cytotoxic drugs employed for the treatment of PM may have played a potential role in only a proportion of patients, opening the possibility that some sALL patients may have developed two or more malignancies due to individual predisposing factors.

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