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Meta-Analysis
. 1999 Oct 16;319(7216):1040-4.
doi: 10.1136/bmj.319.7216.1040.

Is Helicobacter pylori associated with non-ulcer dyspepsia and will eradication improve symptoms? A meta-analysis

R L Jaakkimainen  1 , E Boyle, F Tudiver
Affiliations
Meta-Analysis

Is Helicobacter pylori associated with non-ulcer dyspepsia and will eradication improve symptoms? A meta-analysis

R L Jaakkimainen et al. BMJ. .

Abstract

Objectives: To examine the association between Helicobacter pylori infection and non-ulcer dyspepsia, and to assess the effect of eradicating H pylori on dyspeptic symptoms in patients with non-ulcer dyspepsia.

Design: Systematic review and meta-analysis of (a) observational studies examining the association between Helicobacter pylori infection and non-ulcer dyspepsia (association studies), and (b) therapeutic trials examining the association between eradication of H pylori and dyspeptic symptoms in patients with non-ulcer dyspepsia (eradication trials).

Data sources: Randomised controlled trials and observational studies conducted worldwide and published between January 1983 and March 1999.

Main outcome measures: Summary odds ratios and summary symptom scores.

Results: 23 association studies and 5 eradication trials met the inclusion criteria. In the association studies the summary odds ratio for H pylori infection in patients with non-ulcer dyspepsia was 1.6 (95% confidence interval 1.4 to 1.8). In the eradication trials the summary odds ratio for improvement in dyspeptic symptoms in patients with non-ulcer dyspepsia in whom H pylori was eradicated was 1.9 (1.3 to 2.6).

Conclusions: Some evidence shows an association between H pylori infection and dyspeptic symptoms in patients referred to gastroenterologists. An improvement in dyspeptic symptoms occurred among patients with non-ulcer dyspepsia in whom H pylori was eradicated.

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Figures

Figure 1
Figure 1
Odds ratios and summary odds ratios for association studies
Figure 2
Figure 2
Odds ratios and summary odds ratios for eradication trials
See this image and copyright information in PMC

Comment in

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