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Review
. 1999 Nov;65(5):1215-21.
doi: 10.1086/302631.

Functional and structural brain abnormalities associated with a genetic disorder of speech and language

K E Watkins  1 , D G Gadian, F Vargha-Khadem
Affiliations
Review

Functional and structural brain abnormalities associated with a genetic disorder of speech and language

K E Watkins et al. Am J Hum Genet. 1999 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Pedigree of the KE family
Figure 2
Figure 2
Results of analysis of PET data. Colored areas are regions that are either underactive (A and B) or overactive (C and D) in the affected family members, compared to the activation seen in the control subjects. A, Supplementary motor area and cingulate cortex. Parasagittal section through left hemisphere, 6 mm from midline. B, Left sensorimotor cortex and cingulate cortex. Transverse section, 36 mm above the transverse plane through the anterior commissure (AC). C, Left caudate nucleus (head and tail) and prefrontal cortex. Transverse section, 12 mm above the transverse plane through the AC. D, Left premotor cortex and caudate nucleus. Coronal section, 14 mm in front of the coronal plane through the AC. (Panels A and D reprinted, with permission, from Vargha-Khadem et al. [1998])
Figure 3
Figure 3
Results of morphometric analyses. Colored areas are regions that have either less (A and B) or more (C and D) gray matter in the affected family members compared to the unaffected. A, Left and right caudate nucleus. Transverse section, 9 mm above the transverse plane through the AC. B, Left medial frontal cortex and caudate nucleus. Parasagittal section through the left hemisphere, 10 mm from midline. C, Left and right putamen. Coronal section, 8 mm posterior to the coronal plane through the AC. D, Left inferior frontal cortex (BA45), left anterior insula, and right and left planum temporale. Transverse section, 4 mm above the transverse plane through the AC. (Panel A reprinted, with permission, from Vargha-Khadem et al. [1998])
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