Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Nov;65(5):1215-21.
doi: 10.1086/302631.

Functional and structural brain abnormalities associated with a genetic disorder of speech and language

K E Watkins  1 , D G Gadian, F Vargha-Khadem
Affiliations
Review

Functional and structural brain abnormalities associated with a genetic disorder of speech and language

K E Watkins et al. Am J Hum Genet. 1999 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pedigree of the KE family
Figure 2
Figure 2
Results of analysis of PET data. Colored areas are regions that are either underactive (A and B) or overactive (C and D) in the affected family members, compared to the activation seen in the control subjects. A, Supplementary motor area and cingulate cortex. Parasagittal section through left hemisphere, 6 mm from midline. B, Left sensorimotor cortex and cingulate cortex. Transverse section, 36 mm above the transverse plane through the anterior commissure (AC). C, Left caudate nucleus (head and tail) and prefrontal cortex. Transverse section, 12 mm above the transverse plane through the AC. D, Left premotor cortex and caudate nucleus. Coronal section, 14 mm in front of the coronal plane through the AC. (Panels A and D reprinted, with permission, from Vargha-Khadem et al. [1998])
Figure 3
Figure 3
Results of morphometric analyses. Colored areas are regions that have either less (A and B) or more (C and D) gray matter in the affected family members compared to the unaffected. A, Left and right caudate nucleus. Transverse section, 9 mm above the transverse plane through the AC. B, Left medial frontal cortex and caudate nucleus. Parasagittal section through the left hemisphere, 10 mm from midline. C, Left and right putamen. Coronal section, 8 mm posterior to the coronal plane through the AC. D, Left inferior frontal cortex (BA45), left anterior insula, and right and left planum temporale. Transverse section, 4 mm above the transverse plane through the AC. (Panel A reprinted, with permission, from Vargha-Khadem et al. [1998])
See this image and copyright information in PMC

References

    1. Aglioti S, Beltramello A, Girardi F, Fabbro F (1996) Neurolinguistic and follow-up study of an unusual pattern of recovery from bilingual subcortical aphasia. Brain 119:1551–1564 - PubMed
    1. Arnold GE (1961) The genetic background of developmental language disorders. Folia Phoniatr 13:246–254 - PubMed
    1. Bishop DV, North T, Donlan C (1995) Genetic basis of specific language impairment: evidence from a twin study. Dev Med Child Neurol 37:56–71 - PubMed
    1. Chi JG, Dooling EC, Gilles FH (1977) Left-right asymmetries of the temporal speech areas of the human fetus. Arch Neurol 34:346–348 - PubMed
    1. Eden GF, VanMeter JW, Rumsey JM, Maisog JM, Woods RP, Zeffiro TA (1996) Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature 382:66–69 - PubMed