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Review
. 1999 Oct 15;286(5439):458-62, 479-81.
doi: 10.1126/science.286.5439.458.

The promise of comparative genomics in mammals

S J O'Brien  1 , M Menotti-Raymond, W J Murphy, W G Nash, J Wienberg, R Stanyon, N G Copeland, N A Jenkins, J E Womack, J A Marshall Graves
Affiliations
Review

The promise of comparative genomics in mammals

S J O'Brien et al. Science. .

Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

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