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Clinical Trial
. 1999 Oct;46(10):991-3.
doi: 10.1007/BF03013138.

Ramosetron vs granisetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Y Fujii  1 , Y Saitoh, H Tanaka, H Toyooka
Affiliations
Clinical Trial

Ramosetron vs granisetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Y Fujii et al. Can J Anaesth. 1999 Oct.

Retraction in

Abstract

Purpose: To compare the efficacy of ramosetron with granisetron for the prevention of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.

Methods: In a randomized, double-blind study, 80 female inpatients received 3 mg granisetron or 0.3 mg ramosetron i.v. (n=40 of each) at the completion of surgery The standardized anesthetic included isoflurane and nitrous oxide in oxygen.

Results: Complete response, defined as no PONV, during the first 24 hr (0-24 hr) after anesthesia was 85% with granisetron and 93% with ramosetron, respectively (P=0.241); the corresponding incidence during the next 24 hr (24-48 hr) after anesthesia was 63% and 90% (P=0.004). No clinically important adverse events due to the study drug were observed in any of the groups.

Conclusion: Ramosetron was more effective than granisetron for prevention of PONV during 0-48 hr after anesthesia for laparoscopic cholecystectomy.

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