Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999;8(2-3):151-6.
doi: 10.1002/(sici)1097-0193(1999)8:2/3<151::aid-hbm13>3.0.co;2-5.

Interregional connectivity to primary motor cortex revealed using MRI resting state images

J Xiong  1 , L M Parsons, J H Gao, P T Fox
Affiliations

Interregional connectivity to primary motor cortex revealed using MRI resting state images

J Xiong et al. Hum Brain Mapp. 1999.

Abstract

The topographic organization of cortical neurons is traditionally examined using histological procedures. Functional magnetic resonance imaging (fMRI) offers the potential noninvasively to detect interregional connectivity of human brain. In the brain, there is spontaneous firing of neurons even in the resting state. Such spontaneous firing will increase local blood flow, cause MRI signal fluctuations, and affect remotely located neurons through the efferent output. By calculating covariance of each voxel referenced to the time course of a selected brain region, it is possible to detect the neurons connected to the selected region. Using this covariance method, neural connectivity to primary motor cortex was assessed during a resting state in six healthy right-handed volunteers. This interregional connectivity is similar to connectivity established by other anatomical, histochemical, and physiological techniques. This method may offer in vivo noninvasive measurements of neural projections.

PubMed Disclaimer

References

    1. Biswal B, Yetkin FZ, Haughton VM, Hyde JS. 1995. Functional connectivity in the motor cortex of resting human brain using echo‐planar MRI. Magn Reson Med 34:537–541. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=96107680&form... - PubMed
    1. Dum RP, Strick PL. 1991. Premotor areas: Nodal points for parallel efferent systems involved in the central control of movement In: Humphrey, Freund (eds.): Motor Control: Concepts and Issues. New York: John Wiley & Sons, pp 383–397.
    1. Dum RP, Strick PL. 1993. Cingulate motor areas In: Vogt BA, Gabriel M. (eds.): Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook. Boston: Birkhauser, pp 416–441.
    1. Friston KJ. 1994. Functional and effective connectivity in neuroimaging: A synthesis. Hum Brain Mapp 2:56–78.
    1. Golanov EV, Yamamoto S, Reis DJ. 1994. Spontaneous waves of cerebral blood flow associated with a pattern of electrocortical activity. Am J Physiol 266:R204–R214. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=94136724&form... - PubMed

Publication types

LinkOut - more resources