Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Oct 15;459(3):463-6.
doi: 10.1016/s0014-5793(99)01297-1.

The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding

T Jacobs  1 , M D Cima-Cabal, A Darji, F J Méndez, F Vázquez, A A Jacobs, Y Shimada, Y Ohno-Iwashita, S Weiss, J R de los Toyos
Affiliations
Free article

The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding

T Jacobs et al. FEBS Lett. .
Free article

Abstract

Thiol-activated cytolysins share a conserved hydrophobic, Trp-rich undecapeptide that is suggested to be involved in membrane binding and intercalation. The neutralizing monoclonal antibody PLY-5 recognizes all members of this toxin family and peptide mapping assigned its epitope to the undecapeptide motif. This antibody inhibited binding of the toxins to host cell membranes and the epitope was no longer available for binding when a preformed toxin/membrane complex was tested. These results confirm the model of cytolysin binding suggested by structural data.

PubMed Disclaimer

Publication types

LinkOut - more resources