Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 1999 Oct;26(10):2148-52.

Genetic analysis of the contribution of IL10 to systemic lupus erythematosus

M E Alarcón-Riquelme  1 , A K Lindqvist, I Jonasson, B Johanneson, S Sandino, J Alcocer-Varela, J Granados, H Kristjánsdóttir, G Gröndal, E Svenungsson, I Lundberg, K Steinsson, L Klareskog, G Sturfelt, L Truedsson, D Alarcón-Segovia, U B Gyllensten
Affiliations
  • PMID: 10529131
Multicenter Study

Genetic analysis of the contribution of IL10 to systemic lupus erythematosus

M E Alarcón-Riquelme et al. J Rheumatol. 1999 Oct.

Abstract

Objective: To study the contribution of the IL10 gene to the susceptibility to systemic lupus erythematosus (SLE).

Methods: Analysis by fluorescent-semiautomated genotyping of a dinucleotide repeat located in the promoter region of the IL10 locus (microsatellite G).

Results: No significant difference was found in the frequencies of the microsatellite alleles of 330 Mexican patients with SLE compared to 368 controls from the same population. Two-point linkage analyses were carried out using 13 Mexican, 13 Swedish, and 8 Icelandic families with 2 or more cases with SLE. No linkage was revealed between IL10 and SLE, using a variety of parameter settings.

Conclusion: Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.

PubMed Disclaimer

Publication types

LinkOut - more resources