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. 1999 Oct 16;845(1):107-11.
doi: 10.1016/s0006-8993(99)01952-6.

Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

L Belayev  1 , I Saul, P W Huh, N Finotti, W Zhao, R Busto, M D Ginsberg
Affiliations
Free article

Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

L Belayev et al. Brain Res. .
Free article

Abstract

The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage.

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