Amnioreduction: how much to drain?

Abstract

Objectives: To assess the relationship between the volume of amniotic fluid removed and the change in amniotic fluid index (AFI) and calculate an equation describing this association.

Materials and methods: A retrospective analysis of 19 amnioreduction procedures performed in our unit. Multiple regression analysis was used to assess the effect of gestational age and pre-procedure AFI on the change in AFI (DeltaAFI) after adjusting for the volume removed.

Results: As expected, a significant linear relationship was found between the change in AFI and the volume removed (r = 0.82, n = 19, p < 0.0001). DeltaAFI was not dependent on the gestational age or the pre-procedure AFI. The equation describing the association between the volume removed and DeltaAFI was: volume = (DeltaAFI - 2. 26)/0.008, which is close to 1 cm DeltaAFI for every 100 ml removed.

Discussion: Using the described equation, it is possible to predict the required volume to be removed in order to achieve a particular DeltaAFI, which may reduce the need to interrupt the procedure to measure the AFI. However, the limitation of AFI as a semiquantitative assessment of the liquor volume, together with its inter- and intra-observer variations mean this equation should be used only as a guide.