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. 1999 Oct;25(5):327-32.
doi: 10.1111/j.1447-0756.1999.tb01171.x.

The use of rectal misoprostol as active pharmacological management of the third stage of labor

K M Diab  1 , A R Ramy, M A Yehia
Affiliations

The use of rectal misoprostol as active pharmacological management of the third stage of labor

K M Diab et al. J Obstet Gynaecol Res. 1999 Oct.

Abstract

Objective: To compare the effectiveness of rectal Misoprostol versus combined intramuscular oxytocin and ergometrine (O-E) in the management of the third stage of labor.

Methods: Low-risk women in 3rd stage of labor were allocated to receive either rectal Misoprostol [200micrograms (n = 25), 400 micrograms (n = 45)] or 5-units oxytocin and 0.2 mg ergometrine intramuscularly (n = 75). Clinical and hematological parameters were compared using t and chi-square tests.

Results: Both groups were well matched and had similar duration of the 3rd-stage of labor. Misoprostol users had lower 3rd-stage estimated blood loss and needed less further ecbolics compared to O-E group. Postpartum Hb and Hct levels were significantly lower in O-E group than Misoprostol group. Postpartum hypertension occurred more in O-E group. Subjects in Misoprostol group had more shivering. Subjects receiving 200 micrograms and 400 microgram Misoprostol had similar outcome variables.

Conclusion: Rectal Misoprostol may be used safely in the management of the third stage of labor.

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