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Clinical Trial
. 1999 Nov;41(5 Pt 1):728-32.
doi: 10.1016/s0190-9622(99)70008-3.

A randomized comparison of narrow-band TL-01 phototherapy and PUVA photochemotherapy for psoriasis

P M Gordon  1 , B L Diffey, J N Matthews, P M Farr
Affiliations
Clinical Trial

A randomized comparison of narrow-band TL-01 phototherapy and PUVA photochemotherapy for psoriasis

P M Gordon et al. J Am Acad Dermatol. 1999 Nov.

Abstract

Background: Although PUVA treatment of psoriasis is more effective than conventional or broad-band UVB phototherapy, two small studies have suggested that narrow-band or TL-01 phototherapy may have a therapeutic effect equal to PUVA. If confirmed, this would be of considerable importance as TL-01 therapy is likely to be considerably safer in the long term than PUVA.

Objective: The purpose of this study was to compare PUVA with narrow-band (TL-01) phototherapy in psoriasis.

Methods: We studied 100 patients with plaque-type psoriasis who were randomly allocated to twice-weekly treatment with PUVA or narrow-band UVB.

Results: Clearance of psoriasis was achieved in a significantly greater proportion of patients treated with PUVA (84%) than with TL-01 (63%) (P =.018), and with significantly fewer treatments (median number of treatments for clearance with PUVA, 16.7; with TL-01, 25.3; P =.001). Only 12% of those treated with TL-01 were clear of psoriasis 6 months after finishing treatment compared with 35% for PUVA (P =.002).

Conclusion: When given twice weekly, PUVA is more effective for psoriasis than narrow-band UVB phototherapy.

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